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Heparinized mice were sacrificed and live atria dissected in Tyrode's solution (35 °C) consisting of (in mmol/L) 140 NaCl, 5.4 KCl, 1.2 KH 2 PO 4 , 1.0 MgCl 2 , 1.8 CaCl 2 , 5.55 glucose, and 5 HEPES, with pH adjusted to 7.4 with NaOH

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